Webinar "Evolutionary aspects of molecular allergology and clinical utility of component-resolved diagnostics"

Dear colleagues!

INUNIMAI kindly invites you to participate in the webinar “Evolutionary aspects of molecular allergology and clinical utility of component-resolved diagnostics”.

Webinar will be held July 7, 2016, 12:30 (Moscow time) on internist.ru.

Speaker: Dr. Prof. Head of the Laboratory of Clinical Allergology Marina A. Mokronosova, Institute of Vaccines and Serums named by I. Mechnikov

Abstract

IgE-mediated reactions first appeared in primates as the anti-helminth defense mechanism. This immune response against helminths helped warm-blooded animals to survive and Homo sapiens to appear. Further, this mechanism was transformed into IgE-mediated reactions to plant and animal proteins homologous to helminth ones. Thus, allergy from the evolutionist point of view is a perverted immune response to molecules from different sources, which are homologous to parasitic proteins. Molecules called panallergens have especially strong ability to cause both specific and non-specific reactions. Information about the induction of IgE reactivity to different groups of allergens allows the clinician to predict the severity of pathology and choose right strategy for therapy.

  • Evolution of IgE-mediated reactions: from helminths to allergen components from different sources
  • Characteristics of panallergens, their interactions with IgE-antibodies and clinical utility
  • Examples of panallergens. Tropomyosins – animal panallergens, profilins and pathogen-related group 10 proteins – plant panallergens
  • Autoallergy as the molecular allergology concept
  • Clinical cases