Component-Resolved Diagnostics – New Era in Allergology

Atopy is a hypersensitivity mediated by IgE reactions with different allergens. The mechanism of molecular interactions with antibody epitope is possible when they meet loci size and congruency at the time of complex formation. Traditionally, clinical allergists use extracts from allergen sources for both skin prick tests and in vitro diagnostics. At the same time, each individual patient has individual sensitization profile. This means that antibodies react with individual molecular components from the extract. Type, severity and duration of allergic reaction depend on what molecule from the extract interacts with IgE-epitope. Molecules that often cause clinically relevant reactions are belong to the major allergen components.

For component resolved diagnostics microarrays containing more than 150 molecules are developed.

Plan of the lecture

  1. Molecular allergology as a base of pathophysiological mechanisms and clinical manifestations of atopy
  2. The concept and technology of component resolved diagnostics
  3. The portrait of polysensitization patient (clinical cases)
  4. Main groups of molecular allergen components
  5. Clinical importance of component resolved diagnostics

Speaker

Prof. Marina A. Mokronosova, M.D., Head of the Laboratory of Clinical Allergology, Institute of Vaccines and Serums named by I. Mechnikov

Date and time of the webinar:

June 23, 2016, 12:30 – 13:30 (Moscow time)

Link to the webinar page (in Russian)