INUNIMAI 3rd Training for Trainers "Guide tour to molecular allergy diagnosis on Danube river": event report

The 3rd INUNIMAI Training for Trainers organized by INUNIMAI Heads, Prof. Rudolf Valenta and Prof. Victoria Garib, was held on June 15, 2016, in Vienna, Austria. The aim of the Training was to acquaint with the new guide to molecular allergy diagnostics as well as implementation stages of recombinant vaccines for allergy therapy and prophylaxis. The Training was traditionally attended by leading experts and teachers from universities in Armenia, Belarus, Greece, Georgia, Kazakhstan, Russia, Ukraine and Uzbekistan. The geography of participants of the Training was extended by the representatives of Zimbabwe, Iran and Thailand.

Professor Heimo Breiteneder devoted his lecture to the structural characteristics and clinical relevance of main allergen families and superfamilies. Prof. Victoria Garib followed by the speech about sensitization to panallergens, which are proteins with wide cross-reactivity often considered as minor allergens, talking about their main families and management of pan- and polysensitization development. Discussion about joint projects in clinical research raised the issues of creating the world sensitization map and implementation of the Program “Schoolchild sensitization profile”. Associate Professor, Dr. Michael Wallner from the University of Salzburg told about cross-reactivity of pectate liase allergen family of ambrosia, mugwort and cypress, purification of these allergens and characterization of immune response to their protein isoforms. Taking Amb a 1 allergen as example Dr. Wallner showed the cross-reactivity model of ambrosia major allergen protein isoforms.

The next part of the training could be named “From general to special” as it was devoted to particular and the most important allergens. It was started from the speech of Dr. Irene Mitterman from the Medical University of Vienna about bacterial, yeast and human allergens and their role in atopic dermatitis development, and then Dr. Sandra Wisser proposed to make a virtual walk on field of wheat and study wheat allergens – triggers of food and pollen allergy in details. Christine Hafner showed the panel of latex allergens that often cause allergy in medical and laboratory workers as well as patients with frequent surgical procedures. In her lecture, Birgit Linhart answered the question if AIT to fish allergy is possible and what allergens were selected as candidates for efficient vaccine.

There is no efficient therapy without precise allergy diagnosis. Petra Ziglmeyer made detailed speech about the most effective methods of component-resolved allergy diagnostics and the most importains allergens for AIT prescription, and engineer Felix Gastager told about multiplex analysis and quantification of IgE level. Quantitative results will help to study changes in IgE-response even before clinical symptoms will develop, which allow prescription of the most efficient therapy. Microarray-based ISAC technology by Phadia designed specifically for the most precise IgE quantification in clinical diagnostics. Dr. Szolt Szephaluzi gave detailed view on egg and milk allergy, place and role of component-resolved diagnostics of these allergies in children. Training was finished by the lecture of the INUNIMAI President, Prof. Rudolf Valenta about the latest trends, advances and perspectives in allergy diagnosis and treatment.

Summing up Training results, INUNIMAI Vice-President, Prof. Victoria Garib told participants about activities of the International Platform of the Universities in the field of molecular allergology and immunology, INUNIMAI events and plans in 2016/2017 schoolyear. Special attention was paid to the site, particularly, upcoming mobile version optimized for smartphones and tablets. Based on activity results, Institute of immunology FMBA of Russia, State Institution “Institute of Otolaryngology named under O. Kolomyichenko” National Academy of Medical Sciences of Ukraine and Ukrainian School of Molecular Allergology and Immunology (USMAI) were awarded by INUNIMAI Active Participants certificates. President of USMAI, Head of the clinic of allergology and immunology “Forpost” (Kyiv, Ukraine) Alexander Nazarenko familiarized Training participants with the activity of the School of Molecular Allergology and Immunology – the only INUNIMAI branch. In USMAI lectures and multilevel Sunday trainings for Ukrainian allergists and immunologists are organized regularly, where doctors learn about the latest advances in molecular and clinical allergology and study how to use these knowledge and skills in their everyday work.

Banquet on ship and boating on Danube river became worthy end of the busy day. Here in friendly and relaxed atmosphere colleagues from different countries discussed their impressions, new information and even future joint projects. There is no doubt that most of them come true, and we will know the results on next training in 2017.

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